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Hyaluronic Acid with Chondroitin Zoom

Doctor's Best Hyaluronic Acid with Chondroitin

Code: DBHA001


Quantity of Capsules: 60


Dosage: 1000mg


S$44.90 S$33.90

Availability: In stock

Pill Type: Veggie Caps

Stock Location: B12

  • It is important to take Collagen type 2 supplement on empty stomach. (Other food or supplements should be consumed only 1 hour after consumption of collagen Type 2 supplement)
  • It is highly encouraged to take vitamin C supplements when taking BioCell Collagen, however it is important to note that vitamin C should be taken separately from Collagen Type 2 (1 hour after).   As vitamin C is an important cofactor (substance that is essential for enzyme activity) for collagen type 2 biosynthesis (body natural synthesis of collagen type 2), hence vitamin C is important to enhance the efficacy of Collagen Type 2 in supporting joint and skin health.
  • Collagen type 2 should never be taken in conjunction with collagen type 1 & 3. This is to avoid both collagen types to bind together in the body and form a complete protein, which turns out to be no longer a collagen in the body. Hence, leave at least 1 hour apart between collagen type 2 and collagen type 1 & 3 supplementation.

Doctor’s Best Hyaluronic Acid with Chondroitin Sulfate featuring BioCell Collagen® supports healthy joint structure and youthful skin*

  • BioCell Collagen® is a proven dietary ingredient that contains a patented composition of naturally occurring hydrolyzed collagen type II (60%), chondroitin sulfate (20%), and hyaluronic acid (10%) in a highly absorbable matrix*

  • Clinically proven to help to maintain joint function.

  • Helps maintain youthful skin by enhancing the structure and volume of the skin by supporting the health of connective tissues.*

  • Gluten Free, Non-GMO

 
Benefits of Hyaluronic Acid with Chondroitin Sulfate
  • Enhances healthy joint structure, lubrication and elasticity
  • Helps maintain joint function
  • Promotes youthful looking skin

What is Doctor's Best Hyaluronic Acid with Chondroitin Sulfate?

BioCell Collagen® is a science based, clinically tested dietary ingredient that promotes youthful looking skin, and healthy connective tissues. The active ingredient, BioCell Collagen®, helps maintain joint function. And it helps maintain youthful skin by enhancing the structure and volume of the skin by supporting the health of connective tissues.*

Hyaluronic Acid is a type of building block called a glycosaminoglycan, and it plays an important role in supporting the health of connective tissue.

Chondroitin sulfate is a chemical in cartilage around joints in the body. Doctor’s Best uses chondroitin sulfate with a purity of 90 percent or greater.

Type II collagen is the collagen that makes up moveable joints. Studies have shown that hydrolyzed collagen provides a substantial advantage in bioavailability over non-hydrolyzed collagen, thereby having the potential to enhance healthy joint structure more efficiently.

How does it work?

Components of BioCell Collagen® (hyaluroinic acid, chondroitin sulfate, and collagen type II) can enhance the normal production of proteoglycans in the joint matrix, thereby enhancing healthy joint structure and helping to maintain joint function.

Hyaluronic Acid is a type of building block called a glycosaminoglycan, and it plays an important role in supporting the health of connective tissue. Healthy connective tissue and cartilage maintenance is fundamental in normal skin and joint function. Hyaluronic Acid is highly concentrated in synovial fluid, where it serves to enhance joint lubrication and the elastic structural and functional characteristics of the joint.

Chondroitin sulfate and the other glycosaminoglycans strongly attract water due to the negative charges of their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side chains where water can enter. This combination of solid and liquid gives cartilage a compressible quality that allows it to function in healthy joints.

Why should I take Best Hyaluronic Acid with Chondroitin Sulfate?

As a part of normal physiology, the tensile properties of articular cartilage begin to decline after about age 30. Researchers agree the major visible signs of aging in the skin, joints and eyes are a result of progressive collagen and hyaluronic acid degradation in our tissues. To help, Doctor’s Best uses BioCell Collagen® is a science based, clinically tested dietary ingredient that promotes youthful looking skin, and healthy joints.

Collagen must be taken on an empty stomach. Wait about 30 minutes before eating .

 


Here's some in-depth information on Biocell & Hydrolyzed Collagen for Advanced Joint Care & Skin Revitalization

Collagen Type 2 - Naturally rich in hyaluronic acid, chondroitin sulfate & glucosamine

 

Articular cartilage is the connective tissue found in the synovial joint (knee, wrist, elbow), whereby it acts as a cushion to prevent the joint bones from rubbing against each other.

 

Cartilage is made up of :

 

  1. Collagen type 2 (structural protein) as matrix (framework) [70%]
  2. Proteoglycans (a protein) composed of: [30%]

○        Chondroitin sulfate (glycosaminoglycan)

○        Hyaluronic acid 

○        Non-collagenous proteins

 

  1. Chondrocyte

 


The joint is made up of the collagen and synovial cavity which requires both proteoglycans (chondroitin sulfate and hyaluronic acid) and collagen to thrive and maintain healthy joint function. 

 

 

 

1.     Collagen type 2 :

 

A structural protein, known as triple-helical type II collagen, is found abundantly in connective tissue, working as a matrix to “glue” all proteoglycans together.

 

 

 

  • Acts as a matrix structure to hold essential components together
  • Provide strength and smoothness

 

 

 

2.     Proteoglycans
Composition of various proteins embedded to collagen matrix.  It is essential for resistance of cartilage against shearing loading forces. 

 

  1. I.                    Chondroitin sulfate (Glycosaminoglycan)

 

Essential building block in cartilage matrix.

 

  • Provide strength, flexibility and shock absorption in joints.
  • Stimulate cartilage regeneration hence slows the breakdown of cartilage.
  • Potent anti-inflammatory properties, prevent inflammation of the joint

 

 

 

    II.     Hyaluronic acid
Major lubricating agent of synovial fluid

 

  • Fluid secreted by the lining of the joint to nourish and lubricate the joint for smooth movement. 

 

 

 

3.    Chondrocyte

 

Naturally produced by the body to regulate the continual remodelling of cartilage (balance between removal of existing cartilage and regeneration of new cartilage)

 

  • Regulate the biosynthesis of collagen and proteoglycans
  • Responsible for collagen type 2 and proteoglycans biosynthesis and maintenance 

 

All these components, both collagen and proteoglycans work together to promote joint health. Firstly, the collagen matrix needs to be strong enough for proteoglycans to be embedded on it. Secondly, when proteoglycans are embedded on the collagen matrix, they could support joint health by contributing its distinctive crucial role.

 

Arthritis refers to joint disease, there are many types of arthritis. Although arthritis is commonly seen in old age, arthritis could affect people even at young age. Arthritis could negatively impact the quality of life due to arthritis-related symptoms, including pain, swelling, stiffness and restricted joint movement. At such, when the arthritic conditions deteriorated, it could lead to chronic pain and disability and eventually results in permanent joints alteration. 

Osteoarthritis is a joint disease that results from the breakdown of protective joint cartilage at the ends of the bone. The progression of osteoarthritis results in disability which contributes to joint pain, stiffness, and swelling in the knees, hands and spine.

  • As the loss or breakdown of both collagen type 2 and proteoglycan components is implicated in progression of osteoarthritis, supplementing with type II collagen and proteoglycans (chondroitin and hyaluronic acid) could be a better approach to combat against progression of osteoarthritis.
  • Without the fundamental matrix framework due to the destruction of collagen type 2, this failed to hold all other essential components together, including proteoglycans (chondroitin sulfate and hyaluronic acid), hence induces the loss or breakdown of the overall articular cartilage.

 

Rheumatoid Arthritis is an autoimmune disease (body immune system mistakenly attacks its own tissues) that causes chronic inflammation in the synovial membrane (lining of the joints). This leads to symptoms of pain, swelling, impaired joint functions and fever. If left untreated, rheumatoid arthritis will eventually results in loss of cartilage, hence deteriorates into permanent joint deformity and bone erosion. On top of joint health, rheumatoid arthritis could also affect other parts of the body systems, including respiratory, cardiovascular or even nervous system. Hence, it is important to address the issue of rheumatoid arthritis early.

  

BioCell Collagen

 

Overview

 

The hydrolyzed Collagen type 2 is naturally extracted from chicken sternal cartilage contains a mixture of hydrolyzed type II collagen, hyaluronic acid, chondroitin sulfate, and glucosamine. Such composition is similar to that of human articular cartilage, in which, the composition of BioCell Collagen is not artificial but a naturally occuring matrix composed hydrolysed collagen type 2. Therefore, BioCell Collagen readily replenishes deteriorated collagen type 2, chondroitin sulfate and hyaluronic acid in the joint, either due to old age or other chronic joint conditions. With its higher bioavailability, it is rapidly absorbed by the body and hence significantly promotes joint health and skin beauty.

 

  • It is important to take Collagen type 2 supplement on empty stomach. (Other food or supplements should be consumed only 1 hour after consumption of collagen Type 2 supplement)
  • It is highly encouraged to take vitamin C supplements when taking BioCell Collagen, however it is important to note that vitamin C should be taken separately from Collagen Type 2 (1 hour after).   As vitamin C is an important cofactor (substance that is essential for enzyme activity) for collagen type 2 biosynthesis (body natural synthesis of collagen type 2), hence vitamin C is important to enhance the efficacy of Collagen Type 2 in supporting joint and skin health.
  • Collagen type 2 should never be taken in conjunction with collagen type 1 & 3. This is to avoid both collagen types to bind together in the body and form a complete protein, which turns out to be no longer a collagen in the body. Hence, leave at least 1 hour apart between collagen type 2 and collagen type 1 & 3 supplementation.

What is BioCell Collagen ?

  • BioCell Collagen is superior in providing comprehensive support for the cartilage by delivering highly bioavailable (body readily absorb and utilize) collagen type 2, along with chondroitin sulfate, hyaluronic acid and glucosamine, hence readily stimulate natural collagen biosynthesis in the body,
  • Unlike unhydrolyzed collagen (native form) which is limited to provide only collagen type 2, attributing to its partial effectiveness. BioCell Collagen, on the other hand, is capable in exerting a complete joint support by providing collagen type 2 along with chondroitin sulfate, hyaluronic acid and glucosamine in addition.
  • The patented formula composes both hydrolyzed collagen type 2 and proteoglycans, in which both essential components work in synergically, hence exerting a superior capability in proving its efficacy.
  • Collagen type 2 is extracted from chicken sternum cartilage which contains the greatest amount of proteoglycans, hence capable of cartilage regeneration in arthritis joints.
  • Unlike other joint-related supplements, which could lack human studies to demonstrate the safety and efficacy in supporting joint health? BioCell Collagen has been performed in human clinical trials to prove its safety, efficacy and bioavailability. 
  • BioCell Collagen does not only target the cartilage, but also other components of the joint which includes the tendons, ligaments, and synovial fluid. This explains why BioCell Collagen really works for osteoarthritis-related symptoms. Not only it helps to combat against the osteoarthritis-related symptoms, it also helps to solve the roots of the problem via regression of osteoarthritis condition.
  • As collagen type 2 is also needed for the synthesis and repair of other connective tissues throughout the body, hence all these components work coherently to support overall joint health in the body (which include the elbows, hips, wrist and spines).

 

 

 

Why BioCell Collagen ?

 

 

 

  • Collagen is found abundantly in the body. The most common collagen type is collagen type 1 & 3 which is found predominantly in skin, muscle and bone, whereas collagen type 2 is found primarily in the joints. BioCell Collagen is capable of stimulating the biosynthesis of all major types of collagen (1, 2, and 3), and hence, is beneficial to support both the joint and skin health.
  • Despite the wide usage of glucosamine to combat against the symptoms of osteoarthritis, emerging scientific studies have highlighted the limited efficacy of glucosamine in reducing osteoarthritis-related pain. In fact, glucosamine or chondroitin sulfate alone or in combination does not reduce pain effectively in the overall group of patients with osteoarthritis-related pain.
  • Also, painkillers such as acetaminophen (Panadol) and NSAIDs (Nonsteroidal Anti-Inflammatory Drugs), have been prescribed due to the unbearable pain and stiffness associated to joint inflammation. Not only had these drugs failed to correct the roots of the problem but also cause various unwanted side effects, if prolonged use. (This includes stomach bleeding, liver damage and kidney damage, warned by the FDA). BioCell Collagen, in turn, could provide a safe yet comprehensive solution by reducing osteoarthritis-associated pain along with its capability in stimulating cartilage formation, hence preventing further deterioration of osteoarthritis condition.
  • Proven by human clinical trial, the efficacy of BioCell Collagen in reducing osteoarthritis-related pain and swelling could be observed within 10 weeks, and hence, reduces the need for pain medication (Panadol/ NSAIDs).

 

Reference:

 

 

 

  1. Clegg, D. O., Reda, D. J., Harris, C. L., Klein, M. A., O'dell, J. R., Hooper, M. M., ... & Lane, N. E. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N engl j Med, 2006(354), 795-808.]

 

○         Link: http://www.nejm.org/doi/full/10.1056/NEJMoa052771

 

  1. Schauss, A. G., Stenehjem, J., Park, J., Endres, J. R., & Clewell, A. (2012). Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. Journal of agricultural and food chemistry, 60(16), 4096-4101.

 

○         Link: http://pubs.acs.org/doi/abs/10.1021/jf205295u

 

 

 

Joint Health

 

BioCell Collagen readily provide bioavailable collagen type 2, chondroitin sulfate, hyaluronic acid and glucosamine which are the essential components found in human articular cartilage. Hence, this explains why BioCell Collagen could provide a more complete support for joint health. Belows are the significant results of improved joint health and skin appearance demonstrated by the randomized, double-blinded placebo-controlled human clinical trials performed with daily oral administration of 2,000 mg BioCell Collagen.

 

 

 

1. High bioavailability for rapid absorption

 

 

 

BioCell Collagen provides optimal molecular size of the components (hydrolysed collagen type 2, hyaluronic acid, chondroitin sulfate and glucosamine), this ensures body is able to rapidly absorb it hence increases bioavailability. In comparison to unhydrolyzed (native) collagen type 2, in which the molecular size is too large that could discourage the absorption, and hence significantly reduces the bioavailability (articular cartilage not readily to take up and utilize collagen type 2). 

 

 

 

2. Provide essential structural components

 

 

 

BioCell Collagen provides all essential components which is similar to the structural components found naturally in healthy articular cartilage, ligament, synovial fluid and tendons. This mimicry effects could readily replenish any components that are lacking in the joint, especially during degeneration (impairment) of the joint.

 

 

 

3. Stimulate cartilage chondrocytes

 

 

 

BioCell Collagen is capable of stimulating chondrocyte cells which are responsible to stimulate stable regeneration of cartilage. This could be observed by the increased biosynthesis of collagen type 2, hyaluronic acid and chondroitin sulfate in articular cartilage after oral ingestion of BioCell Collagen. This is particularly important as BioCell Collagen is capable of replenishing the degraded cartilage in certain arthritis condition, such as osteoarthritis.  

 

 

 

 

 

4. Chondroitin as anti-inflammatory properties for joint health

 

 

 

Chondroitin sulfate is capable of reducing joint disease-related pain, swelling and effusion (fluid buildup) attributes to its anti-inflammatory properties. Presence of local inflammation on the articular cartilage has been observed in osteoarthritis which will result in sustained cartilage degeneration, and possibly subchondral bone (bone in between the cartilage) destruction in a long-term. Hence, chondroitin sulfate could beneficially reduce the inflammatory effects in the joint, and therefore, improving overall articular cartilage function.

 

 

 

Although currently there is a lack of scientific research to demonstrate the effects of Collagen type 2 in combating against symptoms of rheumatoid arthritis, one study showed that it could potentially relieve swollen and painful joints in patients suffering from severe rheumatoid arthritis within 3 months. As local inflammation has been observed in rheumatoid arthritis condition as well, hence chondroitin sulfate with its anti-inflammatory capability could help to reduce local joint inflammation, and therefore, potentially combat against symptoms of rheumatoid arthritis. As the current therapeutic solution for rheumatoid arthritis is limited to steroid medications in which long-term usage could results in unwanted side effects. Hence, BioCell Collagen could be consumed as a supplementary joint care support along with other supplements to regulate the immune system. With this, such combination could possibly combat against symptoms of rheumatoid arthritis more effectively.  

 

 

 

5. Hyaluronic acid for joint lubrication

 

 

 

Hyaluronic acid plays an essential role as part of the cartilage to support positive joint healths. Additionally, hyaluronic acid is one of the major lubricating agents that nourish the joint for smooth movement. BioCell Collagen is capable of stimulating hyaluronic acid biosynthesis from synovial cells (cells found in the lining of joint), hence effectively combat against arthritic pain as well as restricted joint movement. This could be proven by a scientific study that demonstrated hyaluronic acid to significantly increased by 60 times after daily consumption of 1,500 mg/ day of BioCell Collagen.

 

 

 

6. Promote effective recovery from strenuous activities

 

 

 

Daily consumption of BioCell Collagen for 6 weeks could effectively promote prompt muscle recovery from strenuous physical activities. It also significantly exerts connective tissue (tendon and ligaments) protection from weight-resistance training, hence enhances muscles and connective tissues repairment and growth during post-workout recovery.

 

 

 

Reference:

 

  1. Lopez, H. L., Habowski, S., Sandrock, J., Kedia, A., & Ziegenfuss, T. (2014). Effects of BioCell Collagen® on connective tissue protection and functional recovery from exercise in healthy adults: a pilot study. Journal of the International Society of Sports Nutrition, 11(Suppl 1), P48. http://doi.org/10.1186/1550-2783-11-S1-P48

 

○         Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271657/

 

  1. Iovu, M., Dumais, G., & Du Souich, P. (2008). Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis and cartilage, 16, S14-S18.

 

○         Link: http://www.oarsijournal.com/article/S1063-4584(08)00202-1/pdf

 

  1. Schauss, A. G., Stenehjem, J., Park, J., Endres, J. R., & Clewell, A. (2012). Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. Journal of agricultural and food chemistry, 60(16), 4096-4101.

 

○         Link: https://www.ncbi.nlm.nih.gov/pubmed/22486722

 

  1. Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., ... & Weiner, H. L. (1993). Effects of oral administration of type II collagen on rheumatoid arthritis. Science, 261(5129), 1727-1730.

 

○         Link: http://science.sciencemag.org/content/261/5129/1727

 

 

 

 

 

Skin Health

 

A healthy skin is made up of three main layers - epidermis (outermost), dermis and subcutaneous layer (innermost). The dermal layer refers to the connective tissue layer which is the main support layer. All components are essential to provide distinctive functions in providing tensile strength, plasticity and elasticity for the skin.  It composed mainly of :

 

 

 

 

 

1.      Collagen

 

 

 

Primarily collagen type 1 & 3 that makes up approximately 75% of the skin’s dry weight.

 

  • Important to provide tensile strength for the skin.
  • Minimize facial fine lines and wrinkles

 

 

 

2.      Elastin fibers

 

 

 

Mesh of proteins with high elasticity capability, hence contributing to the plasticity of the skin.

 

  • Essential to provide structural support for the skin as it allows the skin to regain its original shape after contraction or stretching.

 

 

 

3.      Glycosaminoglycans

 

 

 

Consists mainly of hyaluronic acid, dermatan sulfate and chondroitin sulfate. 

 

 

 

I. Hyaluronic acid
Plays an important role to hydrate the skin by retaining water molecules in the skin dermal layer.

 

 

 

II. Dermatan sulfate
Also known as chondroitin sulfate B, is a natural glycosaminoglycan found in the skin. It is essential for wound repair and blood coagulation properties.

 

III. Chondroitin sulfate
With its anti-inflammatory properties, it serves as a skin-conditioning agent to promote healing, hydrating and soothing skin.

 

 

 

Aging skin is attributed to both internal factors (hormone, cellular metabolism and genetics) and external factors (UV light exposure, environmental pollution and chemicals). All these factors work in coherently to cumulative alterations in skin appearance, resulting in facial fine lines and wrinkles as well as dryness and discoloration in facial appearance. Also, significant reduction in biosynthesis of collagen, elastin fibers and glycosaminoglycans could be observed in aging skin. This attributes to the progressive loss of skin moisture and elasticity.

 

 

 

Anti-Aging

 

 

 

1. Anti-aging properties

 

 

 

BioCell Collagen could significantly improve skin health and conditions from photoaging conditions (premature skin aging due to overexposure of UV ray). Human clinical trials demonstrated that daily consumption of 1 gram of BioCell Collagen shows remarkably reduction in facial wrinkles and fine lines within 12 weeks.

 

 

 

2. Boost facial collagen biosynthesis

 

 

 

An increase in facial collagen type 1 and/or 3 content was measured after 6 weeks of daily ingestion of BioCell Collagen, demonstrating that BioCell Collagen is capable of stimulating biosynthesis of collagen type 1 and/or 3. Human clinical trial shown a visible reduction in fine lines and wrinkles by 13.2% in subjects with photoaging skin conditions. 

 

 

 

3. Improve facial skin dryness and skin scaling

 

 

 

BioCell Collagen is capable of improving overall facial water content by 8% at week 12 during the human clinical trial. This is mainly due to the increased in hyaluronic acid biosynthesis which is capable in retaining water molecules in the skin tissues layer, hence capable of providing hydration and moisture to the skin. 

 

 

 

4. Improve facial blood circulation

 

 

 

BioCell Collagen consumption demonstrates improvement in facial blood circulation which is mainly due to the increased in hemoglobin (red blood cells) amount in the dermal layer. As blood circulation is important to transport oxygen and nutrients, as well as removing metabolic wastes (toxins) from the skin layers, hence enhanced blood circulation could significantly promote beneficial skin health.

 

 

 

Reference:

 

  1. Schwartz, S. R., & Park, J. (2012). Ingestion of BioCell Collagen®, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clinical interventions in aging, 7, 267.

 

○         Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426261/

 

 

 

 

 

 

 

 

 

Product Reviews:

 

i've been taking this for 3 years. i can't live without it. i have horrible knee pain and hip pain for years and nothing worked. after i started this, it's hardly noticeable if ever it returns. great product.” - joer, 55-64 Male on Treatment for 2 to less than 5 years

 

 

 

I have connective tissue disease with chronic pain. I have lost 2.5" of my height from degenerative disc disease. Arthritis pain has taken me over this year. I have muscles and nerves that cause pain. I take 3 major pain meds. Started trying homeopathic products with no relief. Spent $250 trialling products to relieve my pain. Found biocell collagen after much research. The first night taking biocell collagen was the first night in months that I have found some pain relief. This is the product I think I will be able to stick with. Today I have minimal pain. I am very hopeful the biocell collagen will continue working for me and give my joy of life back that chronic pain has taken away.” -  sunny, 55-64 Female on Treatment for less than 1 month

 

Extracted from:
https://www.webmd.com/vitamins-supplements/ingredientreview-1273-BIOCELL+COLLAGEN.aspx?drugid=1273&drugname=BIOCELL+COLLAGEN


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