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Swanson Resveratrol 250 mg Zoom

Swanson Swanson Resveratrol 250 mg

Code: SWU530


Quantity of Capsules: 30


Dosage: 250 mg


S$31.50 S$19.90

Availability: In stock

Pill Type: CAPSULES

Stock Location: E27


Why do the French have the most unhealthy diet, yet their rates of heart disease are the lowest in Europe? Why do they live longer and have better skin, despite all the rich fatty food in their diet? Scientists who studied this phenomenon realised that the answer to the so-called "French paradox" lies in their daily consumption of red wine. Red wine contains an extremely powerful antixoidant called "resveratrol".  

 "After taking Swanson Resveratrol for six months now, I can confidently say that this product has consistently boosted my energy levels and improved my skin health. I highly recommend this product to all my friends'- product review by Maggie Chua, Singapore

Product Description:

A must-have product for everyone who believes that beauty comes from within. Swanson Resveratrol offers you a restorative, age-defying regimen. It is believed to delay the aging effects by preventing free radical damage and promoting cellular activity.

This superior antioxidant formula contains high concentration of resveratrol - a natural ingredient found in red wine. The antioxidant properties found in resveratrol fight free radicals and support anti-ageing and healthy heart. It is made from polygonum, a herb that contains highest amounts of resveratrol, in a form that is more stable than red wine extracts.

 Due to its amazing health benefits, resveratrol has been categorized as a “super food”. It promotes cardiovascular health, boosts immunity and enhances skin and hair health.

 

Learn More:

Resveratrol is a member of a family plant compounds known as polyphenols. It is primarily found in the skin of grapes, especially the red grapes. The other sources of Resveratrol also include berries and peanuts. Most of the resveratrol sold in US contains extracts from Chinese and Japanese knotweed plant known as Polygonum Cuspidatum, while others are made from Red grapes or Red wine. However, Resveratrol extracted from red wine or grapes is not so stable, with a much shorter shelf-life.

Resveratrol is best known for its anti-oxidant properties, which is extremely helpful for healthy skin, hair and eyes.  The primary benefits of Resveratrol involve its anti-aging and disease- combating benefits. Resveratrol is helpful in heart disease as it reduces the inflammation, prevents oxidation of LDL, the bad cholesterol, thus making it difficult for platelets to stick together and form clots. Preventing  oxidation of “bad” cholesterol  is the key to  reducing the risk of  heart attacks.

Resveratrol is also known for limiting the spread of cancer cells in the body and is also known to trigger the death of cancer cells.

Resveratrol is known to prevent insulin resistance in the body, a condition that makes body less sensitive to insulin, a hormone responsible for lowering the blood sugar level. Currently  many studies are being done to see if it may be helpful  in preventing diabetes.

Resveratrol also helps protect nerve cells from damage and the build-up of plaque, which has been associated with Alzheimer’s disease.

Here is an in-depth look at Resveratrol:

 

Resveratrol

 

A non-flavonoid polyphenol found naturally in grapes and red wine. 

 

Properties of Resveratrol

 

1. Antioxidant

 

  • Excessive reactive oxidative species (ROS) induces oxidative stress which will induce damage to DNA, proteins and lipids. All these are proposed to be the underlying mechanisms of chronic diseases and aging.
  • In addition, inflammation further induces oxidative stress, all these factors lead to cumulative damages in the body, resulting in chronic diseases.  
  • Most of the chronic diseases, such as diabetes mellitus, cancer, and atherosclerosis are all associated with chronic inflammation and oxidative stress. Resveratrol is capable in reducing both oxidative stress and inflammation, and hence, combating against oxidative damage in DNA, protein and lipids. 
  • Study has reviewed that resveratrol could be a promising therapy for chronic kidney disease patients in attenuating the progression of disease as well as in reducing risk of cardiovascular disease. This is mainly attributed to its antioxidant capability to combat against oxidative damage.

 

 

 

Reference:  Juliana F. Saldanha, Viviane de O. Leal, Peter Stenvinkel, José Carlos Carraro-Eduardo, and Denise Mafra, “Resveratrol: Why Is It a Promising Therapy for Chronic Kidney Disease Patients?,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 963217, 6 pages, 2013. doi:10.1155/2013/963217

 

 

 

2. Anti-inflammatory

 

  • As chronic inflammation is associated with various chronic diseases, such as atherosclerosis and other cardiovascular events, diabetes, Alzheimer’s disease, and cancer. Resveratrol exhibits anti-inflammatory properties to combat against chronic inflammation, and hence, could potentially help to prevent deterioration of cardiovascular complications.
  • Not only that, resveratrol could  also protect many cell types against inflammation, hence protecting against several chronic diseases related to chronic inflammation such as diabetes, premature skin aging, osteoarthritis. 

 

3. Anti-aging

 

  • Potent activator of longevity gene (SIRT1) which helps to protect against age-related metabolic diseases, such as cancer and glucose intolerance. And hence, resveratrol could possible promote healthy aging. 

 

 

 

4. Telomere length maintenance

 

  • Human telomeres are the protective caps at the end of each DNA strands which is responsible in protecting the chromosomes (a DNA molecule that carries genetic information of individual). During each round of DNA replication (production of identical DNA from a single DNA strand), telomere tends to shorten. The consequences of such process lead to the average telomere length to shorten with increasing age, and hence, leading to limited cell division. When the telomere length is too short or telomeres are dysfunction, the cells can no longer replicate, known as “replicative senescence”. This leads to the cells unable to grow or function normally, and hence, resulting in organs to be more susceptible to diseases as one age.
  • Also, telomeres shortening increases the susceptibility of DNA damage induced by stressors such as UV rays and oxidative damages, this eventually results in cell dysfunctioning and cell death. 
  • Telomere shortening is accelerated by inflammation and oxidative stress in which accelerated telomere shortening is associated with aging, age-related chronic diseases as well as reduced longevity.
  • LTL (leukocyte telomere length) is an indicator of human lifespan whereby the longer the LTL, the longer lifespan of an individual. Resveratrol potentially attenuates telomere shortening by scavenging (neutralize) against reactive oxidative species (ROS) generation in human cells, which in turn, could help to delay rate of cellular replicative senescence as well as increase in DNA repair enzyme.

 

 

 

Reference: Glade, M. J., & Meguid, M. M. (2015). A glance at … telomeres, oxidative stress, antioxidants, and biological aging. Nutrition (Burbank, Los Angeles County, Calif.), 31(11-12), 1447-1451. 10.1016/j.nut.2015.05.018

 

 

 

 

5. Human DNA-repair associated gene

 

  • Resveratrol has shown to be involved with human genome maintenance whereby it enhances human genome encoding for DNA-repair factors, hence potentially preventing aging-related diseases. This demonstrated that resveratrol supplementation could potentially enhance DNA repair systems so as to maintain the cells in healthy state, contributing to the prevention of aging and chronic diseases.  
  • DNA repair and genome (complete genetic information in the body) maintenance is inversely correlated with cellular aging and cancer, in which, cancer has demonstrated to exhibit various cancer-driver gene (genes that drives cancer) that is highly regulated by human cancer genome.

 

 

 

 

 

Reference: Uchiumi F, Arakawa J, Takihara Y, Akui M, Ishibashi S, et al. (2016) The effect of trans-resveratrol on the expression of the human DNA-repair associated genes. Integr Mol Med 3: DOI: 10.15761/IMM.1000246.

 

 

 

 

6. Enhance mitochondrial function

 

  • Mitochondria is the “powerhouse” of the body that is responsible for energy (ATP) production. Energy is very important for bodily cells so as to maintain normal bodily functions. Study has suggested that mitochondrial dysfunction (impairment of mitochondria) is highly associated with development of cancerous cells and other chronic diseases.
  • Resveratrol could help to enhance mitochondrial biogenesis (synthesis of mitochondria by the body) as well as mitochondrial integrity (structure), this could potentially help to regress cancerous cells formation.
  • As cells depend highly on mitochondria to function properly, hence healthy mitochondria helps to regulate cellular energy production, DNA repair, and telomere length in an appropriate fashion.

 

 

 

Reference: Uchiumi F, Arakawa J, Takihara Y, Akui M, Ishibashi S, et al. (2016) The effect of trans-resveratrol on the expression of the human DNA-repair associated genes. Integr Mol Med 3: DOI: 10.15761/IMM.1000246.

 

 

 

 

Health Benefits evidenced by Human Studies

 

1. Diabetes

 

  • Resveratrol improves glycemic control in type 2 diabetes as it improves insulin sensitivity by enhancing pancreas’ function, hence enables the cells to absorb glucose from the bloodstream more efficiently.
  • Human clinical trial demonstrated that twice daily 5 mg of resveratrol consumption is capable of lowering fasting blood glucose levels, and delayed glucose peak in men with type 2 diabetes in 1 month.
  • Daily 250 mg of resveratrol supplementation significantly improved the mean HBA1c ( average blood glucose concentration over the past 3 months) in 3 months.
  • Studies also highlighted that resveratrol supplementation could potentially reverse insulin resistance in people suffering from type 2 diabetes.

 

 

 

Reference: Zhu, X., Wu, C., Qiu, S., Yuan, X., & Li, L. (2017). Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutrition & Metabolism, 14, 60. http://doi.org/10.1186/s12986-017-0217-z

 

 

 

2. Cardiovascular health

 

  • Daily 150 mg of resveratrol effectively reduces systolic blood pressure within 1 month, such effects also observed in people with type 2 diabetes.
  • Resveratrol promotes heart health by improving blood circulation and vascular endothelial function (inner lining of blood vessels). One key observation is the increment of nitric oxide (NO) which is responsible for blood vessels dilation, and hence, increased blood flow. This significantly reduces risk of atherosclerosis.
  • Also, platelet activation is significantly reduced after ingestion of resveratrol supplementation, inferring that resveratrol could potentially reduce incidence of blood clotting in the blood vessels.  All these factors contribute to protecting heart health.
  • Another study demonstrated that daily 10 mg of resveratrol is capable of lowering LDL cholesterol (Low-Density Lipoprotein cholesterol, bad cholesterol) in 3 months. Whilst some other study also suggested the cardioprotective effects of resveratrol could be attributed to its antioxidant and anti-inflammatory capabilities. All these factors work coherently to protecting against coronary artery disease and promoting healthy heart.

 

 

 

Reference: Magyar, K., Halmosi, R., Palfi, A., Feher, G., Czopf, L., Fulop, A., ... & Szabados, E. (2012). Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clinical hemorheology and microcirculation, 50(3), 179-187.

 

 

Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011). Resveratrol and health–a comprehensive review of human clinical trials. Molecular nutrition & food research, 55(8), 1129-1141.

 

 

 

3. Liver Health

 

  • 500 mg of resveratrol daily in conjunction with healthy lifestyle modification reduced ALT (Alanine Aminotransferase, elevated ALT infers liver damage), as well as reduction on hepatic steatosis (fatty liver) in patients with non-alcoholic fatty liver disease.

 

 

 

Reference: Faghihzadeh, F., Adibi, P., & Hekmatdoost, A. (2015). The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: A randomised, double-blind, placebo-controlled study. British Journal of Nutrition, 114(5), 796-803. doi:10.1017/S0007114515002433

 

 

4. Chemotherapeutic Agent (Anti-Cancer)

 

  • Study demonstrated that resveratrol could reduce progression of pre-cancer to cancer stage in women with higher risk of developing breast cancer. This is mainly attributed to activating tumor suppressor gene (RASSF-1a) in the body.  In addition, in patients with colorectal cancer, resveratrol supplementation could potentially reduce rate of cellular proliferation of cancerous tissue by at least 5%.
  • This attributes to the ability of resveratrol in attenuating tumor growth and cause cell death in certain cancer cells, and hence leading to regression in tumor progression.

 

 

 

Reference: W. Zhu, W. Qin, K. Zhang, G.E. Rottinghaus, Y.C. Chen, B. Kliethermes, E.R. SauterTrans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer

 

Nutr. Cancer, 64 (2012), pp. 393-400

 

 

5. Metabolic Effects

 

  • Clinical study demonstrated that daily resveratrol supplementation in healthy, obese human subjects showed overall improvement in energy expenditure and metabolic profile in 1 month.
  • [Abnormal metabolic syndrome infers a cluster of condition, including increased blood pressure, elevated blood glucose level, elevated cholesterol or triglycerides (fats) level, or abdominal obesity. ]
  • Resveratrol enhances skeletal muscle mitochondrial efficiency by increasing gene expression encoding for mitochondrial biogenesis and function. All these factors attribute to beneficial metabolic alterations, such as reduced blood triglyceride and glucose levels. In fact, study highlighted that resveratrol supplementation is able to exert mimicry effects of calorie restriction.
  • [Calorie restriction refers to nutritional interventions that effectively exerts several health benefits by protecting against diabetes, obesity and cardiovascular diseases.]

 

 

 

Reference: Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., ... & Moonen-Kornips, E. (2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell metabolism, 14(5), 612-622.

 

 

 6. Attenuate exercise-induced health benefits

 

  • Resveratrol taken in concomitant training attenuated the exercise-induced health benefits, including reduction in blood pressure and blood lipids, alteration in the balance between prostanoid vasodilators and vasoconstrictors, leading to significantly lower enhancement in maximal oxygen uptake induced by exercise. [Based on 8 weeks of exercise training induced a number of beneficial cardiovascular effects in aged man]
  • Decrease in maximal oxygen uptake attenuated the improvement of aerobic power, in which resveratrol supplementation leads to 45% lower increased in maximal oxygen uptake. It could highly due to its antioxidant properties whereby increment in maximal oxygen uptake with endurance training is mediated by ROS, whilst resveratrol could exert antioxidant defense against ROS, and hence attenuate exercise-induced increase in maximal oxygen uptake indirectly.

 

 

 

Reference: Gliemann, L., Schmidt, J. F., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., … Hellsten, Y. (2013). Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. The Journal of Physiology, 591(Pt 20), 5047–5059. http://doi.org/10.1113/jphysiol.2013.258061

 


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    Resveratrol 250

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